protein family abnormalities and defective erythropoiesis through activation of p53 Ribosomal protein S19 deficiency in zebrafish leads to developmental

@inproceedings{Danilova2008proteinFA,
  title={protein family abnormalities and defective erythropoiesis through activation of p53 Ribosomal protein S19 deficiency in zebrafish leads to developmental},
  author={Nadia Danilova and Kathleen M Sakamoto and Shuo Lin},
  year={2008}
}
Mutations in several ribosomal proteins (RPs) lead to Diamond-Blackfan Anemia (DBA), a syndrome characterized by defective erythropoiesis, congenital anomalies, and increased frequency of cancer. RPS19 is the most frequently mutated RP in DBA. RPS19 deficiency impairs ribosomal biogenesis, but how this leads to DBA or cancer remains unknown. We have found that RPS19 deficiency in zebrafish results in hematopoietic and developmental abnormalities resembling DBA. Our data suggest that the RPS19… CONTINUE READING

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