ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria.

@article{Corrigan2016ppGppNI,
  title={ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria.},
  author={Rebecca M. Corrigan and Lauren E Bellows and Alison Wood and Angelika Gr{\"u}ndling},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 12},
  pages={E1710-9}
}
The stringent response is a survival mechanism used by bacteria to deal with stress. It is coordinated by the nucleotides guanosine tetraphosphate and pentaphosphate [(p)ppGpp], which interact with target proteins to promote bacterial survival. Although this response has been well characterized in proteobacteria, very little is known about the effectors of this signaling system in Gram-positive species. Here, we report on the identification of seven target proteins for the stringent response… CONTINUE READING

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2012)Direct regulation ofGTPhomeostasis by (p)ppGpp: a critical component of viability and stress resistance

  • A Kriel
  • Mol Cell 48(2):231-241
  • 2012
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