ppGpp couples transcription to DNA repair in E. coli

@article{Kamarthapu2016ppGppCT,
  title={ppGpp couples transcription to DNA repair in E. coli},
  author={Venu Kamarthapu and Vitaly Epshtein and Bradley Benjamin and Sergey Proshkin and Alexander Mironov and Michael Cashel and Evgeny Nudler},
  journal={Science},
  year={2016},
  volume={352},
  pages={993-996}
}
The small molecule alarmone (p)ppGpp mediates bacterial adaptation to nutrient deprivation by altering the initiation properties of RNA polymerase (RNAP). ppGpp is generated in Escherichia coli by two related enzymes, RelA and SpoT. We show that ppGpp is robustly, but transiently, induced in response to DNA damage and is required for efficient nucleotide excision DNA repair (NER). This explains why relA-spoT-deficient cells are sensitive to diverse genotoxic agents and ultraviolet radiation… CONTINUE READING
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