pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

  title={pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence},
  author={Eva C. Boritsch and Wafa Frigui and Alessandro Cascioferro and Wladimir Malaga and Gilles Etienne and Françoise Laval and Alexandre Pawlik and Fabien le Chevalier and Mickael Orgeur and Laurence Ma and Christiane Bouchier and Timothy P Stinear and Philip Supply and Laleh Majlessi and Mamadou Daff{\'e} and Christophe Guilhot and Roland Brosch},
  journal={Nature Microbiology},
Mycobacterium tuberculosis is a major, globally spread, aerosol-transmitted human pathogen, thought to have evolved by clonal expansion from a Mycobacterium canettii-like progenitor. In contrast, extant M. canettii strains are rare, genetically diverse, and geographically restricted mycobacteria of only marginal epidemiological importance. Here, we show that the contrasting evolutionary success of these two groups is linked to loss of lipooligosaccharide biosynthesis and subsequent morphotype… CONTINUE READING
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