piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells.

@article{Cox2000piwiEA,
  title={piwi encodes a nucleoplasmic factor whose activity modulates the number and division rate of germline stem cells.},
  author={Daniel N Cox and Angel Chao and Haifan Lin},
  journal={Development},
  year={2000},
  volume={127 3},
  pages={503-14}
}
piwi represents the first class of genes known to be required for stem cell self-renewal in diverse organisms. In the Drosophila ovary, piwi is required in somatic signaling cells to maintain germline stem cells. Here we show that piwi encodes a novel nucleoplasmic protein present in both somatic and germline cells, with the highly conserved C-terminal region essential for its function. Removing PIWI protein from single germline stem cells significantly decreases the rate of their division… CONTINUE READING
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Systematic gainoffunction genetics in Drosophila

  • P. Rorth, K. Szabo, +8 authors S. M. Cohen
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