piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning.

@article{Schuldiner2008piggyBacbasedMS,
  title={piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning.},
  author={Oren Schuldiner and Daniela Berdnik and Jonathan M Levy and Joy S Wu and David Luginbuhl and Allison Camille Gontang and Liqun Luo},
  journal={Developmental cell},
  year={2008},
  volume={14 2},
  pages={227-38}
}
Developmental axon pruning is widely used to refine neural circuits. We performed a mosaic screen to identify mutations affecting axon pruning of Drosophila mushroom body gamma neurons. We constructed a modified piggyBac vector with improved mutagenicity and generated insertions in >2000 genes. We identified two cohesin subunits (SMC1 and SA) as being essential for axon pruning. The cohesin complex maintains sister-chromatid cohesion during cell division in eukaryotes. However, we show that the… CONTINUE READING
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