piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline

@inproceedings{Lim2009piRNAsMP,
  title={piRNAs mediate posttranscriptional retroelement silencing and localization to pi-bodies in the Drosophila germline},
  author={Ai Khim Lim and Liheng Tao and Toshie Kai},
  booktitle={The Journal of cell biology},
  year={2009}
}
Nuage, a well-conserved perinuclear organelle found in germline cells, is thought to mediate retroelement repression in Drosophila melanogaster by regulating the production of Piwi-interacting RNAs (piRNAs). In this study, we present evidence that the nuage-piRNA pathway components can be found in cytoplasmic foci that also contain retroelement transcripts, antisense piRNAs, and proteins involved in messenger RNA (mRNA) degradation. These mRNA degradation proteins, decapping protein 1/2 (DCP1/2… CONTINUE READING