piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals.

Abstract

Endogenous bornavirus-like nucleoprotein elements (EBLNs) are sequences within vertebrate genomes derived from reverse transcription and integration of ancient bornaviral nucleoprotein mRNA via the host retrotransposon machinery. While species with EBLNs appear relatively resistant to bornaviral disease, the nature of this association is unclear. We… (More)
DOI: 10.1261/rna.052092.115

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