pfmdr2 confers heavy metal resistance to Plasmodium falciparum.

  title={pfmdr2 confers heavy metal resistance to Plasmodium falciparum.},
  author={Elli Rosenberg and Ilena Litus and Nurit Schwarzfuchs and Rosa Sinay and Pnina Schlesinger and Jacob Golenser and Stefan Baumeister and Klaus R. Lingelbach and Yaakov Pollack},
  journal={The Journal of biological chemistry},
  volume={281 37},
Heavy metals are required by all organisms for normal function, but high levels of heavy metals are toxic. Therefore, homeostasis of these metals is crucial. In the human malaria-causing agent Plasmodium falciparum, the mechanisms of heavy metal transport have yet to be characterized. We have developed a P. falciparum line resistant to heavy metals from a wild-type line sensitive to heavy metals. A molecular and biochemical analysis of the involvement of the P. falciparum multidrug resistance 2… CONTINUE READING
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