pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin.

@article{Vieira2004pfcrtPA,
  title={pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin.},
  author={Pedro Paulo Ribeiro Vieira and Marcelo U Ferreira and Maria das Graças Costa Alecrim and Wilson Duarte Alecrim and Luiz Hidelbrando P da Silva and Moises M Sihuincha and Deirdre A. Joy and Jianbing Mu and Xin-zhuan Su and Mariano Gustavo Zalis},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={190 2},
  pages={417-24}
}
The widespread occurrence of drug-resistant malaria parasites in South America presents a formidable obstacle to disease control in this region. To characterize parasite populations and the chloroquine-resistance profile of Plasmodium falciparum in the Amazon Basin, we analyzed a DNA segment of the pfcrt gene, spanning codons 72-76, and genotyped 15 microsatellite (MS) markers in 98 isolates from 6 areas of Brazil, Peru, and Colombia where malaria is endemic. The K76T mutation, which is… CONTINUE READING
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