pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo.

@article{Shelton1993pelleEA,
  title={pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo.},
  author={Christopher A. Shelton and Steven A. Wasserman},
  journal={Cell},
  year={1993},
  volume={72 4},
  pages={515-25}
}
The pelle gene is required for the nuclear import of dorsal protein that establishes dorsoventral polarity in Drosophila embryos. We report here the genetic mapping and molecular characterization of pelle. DNA sequence analysis revealed that pelle encodes a protein of 501 amino acids, the last 292 of which comprise a protein kinase catalytic domain. Microinjection of in vitro synthesized transcripts containing site-directed mutations indicates that the kinase catalytic domain is required for… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 89 references

Crystal structure

D. R. Knighton, J. H. Zheng, +4 authors J. M. Sowadski
1991
View 16 Excerpts
Highly Influenced

The gene Serrare encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melancgasrer

R. J. Fleming, T. Scottgale-Nelson, Diederich, J R., S. ArtavanisTsakonas
Genes Dev • 1990
View 1 Excerpt
Highly Influenced

Dorsal-ventral polarity in the Drosophila embryo.

Current opinion in genetics & development • 1993

Nuclear translocation of viral Jun but not of cellular Jun is cell cycle dependent.

Proceedings of the National Academy of Sciences of the United States of America • 1992
View 1 Excerpt

Similar Papers

Loading similar papers…