pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up

@article{Elston1991pathologicalPF,
  title={pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up},
  author={Christopher W. Elston and I. O. Ellis},
  journal={Histopathology},
  year={1991},
  volume={19}
}
Morphological assessment of the degree of differentiation has been shown in numerous studies to provide useful prognostic information in breast cancer, but until recently histological grading has not been accepted as a routine procedure, mainly because of perceived problems with reproducibility and consistency. [] Key Result Histological grade, assessed in 1831 patients, shows a very strong correlation with prognosis; patients with grade I tumours have a significantly better survival than those with grade II…

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long‐term follow‐up. C. W. Elston & I. O. Ellis. Histopathology 1991; 19; 403–410

It is clear that the most important prognostic factors in breast cancer remain the traditional histopathological features of tumour size, lymph node stage and histological grade and the NPI, which has also been validated in other series is being used increasingly to stratify patients for therapeutic purposes.

Pathological prognostic factors in breast cancer. IV: Should you be a typer or a grader? A comparative study of two histological prognostic features in operable breast carcinoma

It is concluded that tumours should be typed and graded in order to predict prognosis most accurately and to enable the choice of optimum treatment for women with primary breast carcinoma.

Pathological prognostic factors in breast cancer. II. Histological type. Relationship with survival in a large study with long‐term follow‐up

The results confirm that histological typing of human breast carcinoma can provide useful prognostic information and show that tubular mixed carcinoma in particular has an extremely good prognosis similar to tumours included in the ‘special type’ category above.

Histological Aspects and Quantitative Assessment of Ki67 as Prognostic Factors in Breast Cancer Patients: Result from a Single-Center, Cross Sectional Study

Both overall survival and progression-free survival may be influenced by the higher value of Ki67 and less differentiated tumors, and further studies are needed in order to establish if the histologic type may impact breast cancer prognostic.

Prognostic value of different cut-off levels of Ki-67 in breast cancer: a systematic review and meta-analysis of 64,196 patients

Ki-67 has an independent prognostic value in terms of OS in BC patients, and the Ki-67 threshold with the greatest prognostic significance is as yet unknown, but a cut-off >25 % is associated with a greater risk of death compared with lower expression rates.

Long-Term Prognostic Performance of Ki 67 Rate in Early Stage , pT 1pT 2 , pN 0 , Invasive Breast Carcinoma

It is concluded that Ki67 is a potential cost-effective decision marker for adjuvant therapy in early-stage HG1, pT1–pT2, pN0, breast cancers and a potential prognostic factor in small size node negative breast cancer.

Comparative evaluation of nuclear and histological grades as prognostic factors for invasive breast cancer

Both NG and HG predict outcomes for breast cancer patients, but the latter might appear to be superior as a three-grade classification scale, although not a few patients exhibited discordant results.

Correlation of various histopathologic prognostic factors with Nottingham prognostic index and microvessel density in invasive breast carcinoma: A study of 100 cases.

NPI is an important and useful prognostic indicator for breast cancer patients, which shows the correlation with other histomorphological prognostic features as well.

Study to evaluate the clinicopathological characteristics and prognostic factors in patients of breast carcinoma below 35 years of age (a study of 200 cases)

Tumors in younger patients had higher co-morbidity and better screening procedures should be used even in females younger than 35 years of age, as breast cancer is uncommon in young women but it co-relates with a less favorable prognosis.

Prognostic value of histologic grade and proliferative activity in axillary node-positive breast cancer: results from the Eastern Cooperative Oncology Group Companion Study, EST 4189.

  • J. SimpsonR. Gray N. Robert
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2000
A subset of axillary lymph node-positive patients with improved prognosis may be identified using a lower (< 3 mitoses/10 HPF) mitotic count than is usually performed.
...

References

SHOWING 1-10 OF 62 REFERENCES

The assessment of histological differentiation in breast cancer.

  • C. Elston
  • Medicine
    The Australian and New Zealand journal of surgery
  • 1984
Histological grade has been assessed in 625 patients with primary breast carcinoma and there is a strong correlation with prognosis; patients with well differentiation tumours have a significantly better survival than those with poorly differentiated tumours (P less than 0.0005).

The importance of histologic grade in long-term prognosis of breast cancer: a study of 1,010 patients, uniformly treated at the Institut Gustave-Roussy.

The data support that performing the modified histoprognostic grading of Scarff and Bloom is simple, reproducible, incurs no additional cost, may be carried out in the simplest histology laboratory, and defines an important risk factor in all patients.

Prognosis in breast cancer utilizing histologic characteristics of the primary tumor

A positive association between the cellular responses to areas of in situ carcinoma and the cellular response to accompanying invasive breast cancer is found, adding to the general understanding of immunogenicity of breast cancer tissue.

Prognosis in breast cancer utilizing histologic characteristics of the primary tumor

A positive association between the cellular responses to areas of in situ carcinoma and the cellular response to accompanying invasive breast cancer is found, adding to the general understanding of immunogenicity of breast cancer tissue.

Further Studies on Prognosis of Breast Carcinoma

  • H. Bloom
  • Medicine
    British Journal of Cancer
  • 1950
The object now is to investigate some further aspects of prognosis in breast cancer on which, from time to time, widely differing opinions have been expressed.

Histological grading in carcinoma of the breast.

  • B. Wolff
  • Medicine
    British Journal of Cancer
  • 1966
IN 1950 Bloom published a paper on the histological grading of mammary tumours and its possible correlation with prognosis in carcinoma of the breast. He was not the first to consider the importance

A retrospective cohort study of histologic risk factors in breast cancer patients

Multivariate analysis of the data by Cox's proportional hazard regression techniques confirmed the importance of the histologic risk factors reflecting the tumor growth potential and demonstrated that lack of tubule formation was the most important single risk factor.

Prognosis in carcinoma of the breast.

  • R. Scarff
  • Medicine
    The British journal of radiology
  • 1948

Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.

It is concluded that neu overexpression may be an early step in the development of a distinct histologic type of carcinoma of the breast, but it could find no association of overeexpression with lymph-node status or tumor recurrence.
...