pat-4/ILK and unc-112/Mig-2 are required for gonad function in Caenorhabditis elegans.

@article{Xu2006pat4ILKAU,
  title={pat-4/ILK and unc-112/Mig-2 are required for gonad function in Caenorhabditis elegans.},
  author={Xiaojian Xu and Sharath C Rongali and Jonathan P Miles and Kap Duk Lee and Myeongwoo Lee},
  journal={Experimental cell research},
  year={2006},
  volume={312 9},
  pages={1475-83}
}
Tissue morphogenesis requires proper interaction between cells and the extracellular matrix (ECM), which is mediated by alphabeta heterodimeric receptor integrin. In Caenorhabditis elegans, integrin signaling is essential for formation of gonad. Here, we probe the role of several integrin-associated molecules in ovulation and cell migration. Function of pat-4/integrin-linked kinase (ILK) and unc-112/Mig-2 was examined using RNA-mediated interference (RNAi). Depletion of these messages caused… CONTINUE READING