painless, a Drosophila Gene Essential for Nociception

@article{Tracey2003painlessAD,
  title={painless, a Drosophila Gene Essential for Nociception},
  author={W. D. Tracey and Rachel I. Wilson and Gilles Laurent and Seymour Benzer},
  journal={Cell},
  year={2003},
  volume={113},
  pages={261-273}
}
We describe a paradigm for nociception in Drosophila. In response to the touch of a probe heated above 38 degrees C, Drosophila larvae produce a stereotypical rolling behavior, unlike the response to an unheated probe. In a genetic screen for mutants defective in this noxious heat response, we identified the painless gene. Recordings from wild-type larval nerves identified neurons that initiated strong spiking above 38 degrees C, and this activity was absent in the painless mutant. The painless… Expand
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