painless, a Drosophila Gene Essential for Nociception

  title={painless, a Drosophila Gene Essential for Nociception},
  author={W.Daniel Tracey and R. Wilson and G. Laurent and S. Benzer},
  • W.Daniel Tracey, R. Wilson, +1 author S. Benzer
  • Published 2003
  • Medicine, Biology
  • Cell
  • We describe a paradigm for nociception in Drosophila. In response to the touch of a probe heated above 38 degrees C, Drosophila larvae produce a stereotypical rolling behavior, unlike the response to an unheated probe. In a genetic screen for mutants defective in this noxious heat response, we identified the painless gene. Recordings from wild-type larval nerves identified neurons that initiated strong spiking above 38 degrees C, and this activity was absent in the painless mutant. The painless… CONTINUE READING
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