pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation

BACKGROUND The onset of differentiation-specific gene expression in skeletal muscle is coupled to permanent withdrawal from the cell cycle. The retinoblastoma tumor-suppressor protein (pRb) is a critical regulator of this process, required for both cell-cycle arrest in G0 phase and high-level expression of late muscle-differentiation markers. Although the… CONTINUE READING