pRb-Independent growth arrest and transcriptional regulation of E2F target genes.

@article{McCabe2005pRbIndependentGA,
  title={pRb-Independent growth arrest and transcriptional regulation of E2F target genes.},
  author={Michael T McCabe and Odinaka J Azih and Mark L. Day},
  journal={Neoplasia},
  year={2005},
  volume={7 2},
  pages={141-51}
}
The retinoblastoma tumor suppressor (pRb) has traditionally been studied as a negative regulator of cell cycle progression through its interactions with the E2F family of transcription factors. Utilizing prostate epithelial cell lines established from Rb+/+ and Rb-/- prostate tissues, we previously demonstrated that Rb-/- epithelial cells were not transformed and retained the ability to differentiate in vivo despite the lack of pRb. To further study the effects of pRb loss in an epithelial cell… CONTINUE READING