pRB and p107 have distinct effects when expressed in pRB-deficient tumor cells at physiologically relevant levels

@article{Jiang2000pRBAP,
  title={pRB and p107 have distinct effects when expressed in pRB-deficient tumor cells at physiologically relevant levels},
  author={Hong Jiang and Anthony N Karnezis and Mingyuan Tao and Peter M Guida and Liang Zhu},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={3878-3887}
}
A key difference among the three structurally similar pRB family members is that only pRB is a tumor suppressor. Identification of distinctive functional differences between pRB and p107/p130 therefore holds promise for a better understanding of the tumor suppression mechanisms of pRB. Enigmatically, pRB and p107 have been shown to have indistinguishable growth suppression activities when studied in the pRB-deficient Saos-2 cell system. In this study, we discovered that, when expressed at… CONTINUE READING
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