pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells

@article{Zhou2013pORF5PP,
  title={pORF5 plasmid protein of Chlamydia trachomatis induces MAPK-mediated pro-inflammatory cytokines via TLR2 activation in THP-1 cells},
  author={Hui Zhou and Qiulin Huang and Zhongyu Li and Yimou Wu and Xiaobing Xie and KangKang Ma and Wenjuan Cao and Zhou Zhou and Chunxue Lu and Guangming Zhong},
  journal={Science China Life Sciences},
  year={2013},
  volume={56},
  pages={460-466}
}
Infection with Chlamydia trachomatis induces inflammatory pathologies in the urogenital tract that can lead to infertility and ectopic pregnancy. Pathogenesis of infection has been mostly attributed to excessive cytokine production. However, precise mechanisms on how C. trachomatis triggers this production, and which protein(s) stimulate inflammatory… CONTINUE READING