pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.

@article{Pouyssgur2001pHiAG,
  title={pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.},
  author={Jacques Pouyss{\'e}gur and Antonella Franchi and Gilles Pag{\'e}s},
  journal={Novartis Foundation symposium},
  year={2001},
  volume={240},
  pages={
          186-96; discussion 196-8
        }
}
Signalling via growth factors, oncogenes and environmental stresses such as hypoxia, promotes the up-regulation of glycolysis, intracellular pH (pHi) and vascular endothelial growth factor (VEGF) via cooperative mechanisms. Somatic cell genetics was applied to a fibroblastic cell line (CCOL39) to disrupt either aerobic glycolysis, respiration, or a major pHi-regulating system, the Na-H exchanger (NHE1). We obtained stable mutants impaired either in phosphoglucose isomerase (pgi-), which produce… CONTINUE READING
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