pH-triggered chitosan nanogels via an ortho ester-based linkage for efficient chemotherapy.

@article{Yang2017pHtriggeredCN,
  title={pH-triggered chitosan nanogels via an ortho ester-based linkage for efficient chemotherapy.},
  author={Guanqing Yang and Xin Wang and Shengxiang Fu and Rupei Tang and Jun Wang},
  journal={Acta biomaterialia},
  year={2017},
  volume={60},
  pages={
          232-243
        }
}
We report on new types of chitosan-based nanogels via an ortho ester-based linkage, used as drug carriers for efficient chemotherapy. First, we synthesized a novel diacrylamide containing ortho ester (OEAM) as an acid-labile cross-linker. Subsequently, methacrylated succinyl-chitosan (MASCS) was prepared and polymerized with OEAM at different molar ratios to give a series of pH-triggered MASCS nanogels. Doxorubicin (DOX) as a model anticancer drug was loaded into MASCS nanogels with a loading… CONTINUE READING