pH transients evoked by excitatory synaptic transmission are increased by inhibition of extracellular carbonic anhydrase.

@article{Chen1992pHTE,
  title={pH transients evoked by excitatory synaptic transmission are increased by inhibition of extracellular carbonic anhydrase.},
  author={Jianhua Chen and Mitchell Chesler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 16},
  pages={7786-90}
}
Excitatory synaptic transmission has been associated with a rapid alkalinization of the brain extracellular space. These pH shifts are markedly increased by acetazolamide, an inhibitor of carbonic anhydrase. Although this effect can be readily explained by inhibition of extracellular carbonic anhydrase, this enzyme has been considered strictly intracellular in the central nervous system. To determine whether these alkaline shifts are regulated by extracellular carbonic anhydrase, we studied the… CONTINUE READING

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