pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.

@article{Jiang2015pHsusceptibilityOH,
  title={pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM catalytic activity.},
  author={Wei Jiang and Michael J. Strohman and Sriram Somasundaram and Sashi Ayyangar and Tieying Hou and Nan Wang and Elizabeth D Mellins},
  journal={Scientific reports},
  year={2015},
  volume={5},
  pages={17333}
}
The peptide-exchange catalyst, HLA-DM, and its inhibitor, HLA-DO control endosomal generation of peptide/class II major histocompatibility protein (MHC-II) complexes; these complexes traffic to the cell surface for inspection by CD4+ T cells. Some evidence suggests that pH influences DO regulation of DM function, but pH also affects the stability of polymorphic MHC-II proteins, spontaneous peptide loading, DM/MHC-II interactions and DM catalytic activity, imposing challenges on approaches to… CONTINUE READING

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