pH stability and activity curves of pepsin with special reference to their clinical importance.

@article{Piper1965pHSA,
  title={pH stability and activity curves of pepsin with special reference to their clinical importance.},
  author={Douglas W. Piper and Barbara H. Fenton},
  journal={Gut},
  year={1965},
  volume={6},
  pages={506 - 508}
}
The concept of peptic ulceration and its treatment is based on the ulcerogenic action of acid and pepsin (Card, 1952). It appears that pepsin plays the predominant role in this action (Schiffrin, 1940; Schiffrin and Warren, 1942; Le Veen, 1947), the acid merely providing the correct pH for optimal peptic activity. Consequently, it is of some importance to know the effect ofpH on the peptic activity of pepsin. One of these effects, the effect of pH on peptic activity, has been adequately studied… 
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TLDR
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TLDR
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TLDR
It seems established that, in duodenal ulcer at any rate, because of the increased volume of gastric secretion, the total output of pepsin by the mucous membrane both at rest and in response to a given stimulus is usually greater than in normal subjoets.
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TLDR
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TLDR
The changes which take place in the glands during digestion are briefly touched upon, and it will be seen that these points if proved establish certain fundamental resemblances in life-habit between the chief-cells of the gastric glands of mammals, the cells of the stomach glands of the lower vertebrates' and the Cells of the pancreatic gland.
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TLDR
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