pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates.

  title={pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates.},
  author={Arnaud E Felber and Marie-H{\'e}l{\`e}ne Dufresne and Jean-Christophe Leroux},
  journal={Advanced drug delivery reviews},
  volume={64 11},
Titratable polyanions, and more particularly polymers bearing carboxylate groups, have been used in recent years to produce a variety of pH-sensitive colloids. These polymers undergo a coil-to-globule conformational change upon a variation in pH of the surrounding environment. This conformational change can be exploited to trigger the release of a drug from a drug delivery system in a pH-dependent fashion. This review describes the current status of pH-sensitive vesicles, polymeric micelles… CONTINUE READING

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