pH-sensitive tubular polymersomes: formation and applications in cellular delivery.

@article{Robertson2014pHsensitiveTP,
  title={pH-sensitive tubular polymersomes: formation and applications in cellular delivery.},
  author={James D Robertson and Guy M. Yealland and Milagros Avila-Olias and Luca Chierico and Oliver Bandmann and Stephen A. Renshaw and Giuseppe Battaglia},
  journal={ACS nano},
  year={2014},
  volume={8 5},
  pages={
          4650-61
        }
}
Optimizing the shape of a nanovector influences its interaction with a cell and determines the internalization kinetics. Block copolymer amphiphiles self-assemble into monodisperse structures in aqueous solutions and have been explored extensively as drug delivery vectors. However, the structure of self-assembled block copolymers has mainly been limited to spherical vesicles or spherical and worm-like micelles. Here we show the controlled formation and purification of tubular polymersomes, long… CONTINUE READING
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