pH-sensitive polymer hydrogels derived from morpholine to prevent the crystallization of ibuprofen.

@article{Velasco2011pHsensitivePH,
  title={pH-sensitive polymer hydrogels derived from morpholine to prevent the crystallization of ibuprofen.},
  author={Diego Velasco and Ch B Danoux and Juan Alfonso Redondo and Carlos Elvira and Julio San Rom{\'a}n and Patrick S Wray and Sergei G. Kazarian},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={149 2},
  pages={140-5}
}
Various pharmaceutical formulations of ibuprofen are available including oral tablets, suspensions, suppositories and transdermal gels and creams. Aqueous ibuprofen solubility is dependent on pH increasing solubility when increasing pH. The very low aqueous solubility of ibuprofen can lead to a segregation of the drug in to microdomains and possible crystallization which will affect the release profile even leading to possible damage of the mucous membrane of the stomach. Therefore… CONTINUE READING
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