pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease.

  title={pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease.},
  author={Ana Beloqui and R{\'e}gis Coco and Patrick B. Memvanga and Bernard Ucakar and Anne des Rieux and V{\'e}ronique Pr{\'e}at},
  journal={International journal of pharmaceutics},
  volume={473 1-2},
Nano-scaled particles have been found to preferentially accumulate in inflamed regions. Local delivery of anti-inflammatory drugs loaded in nanoparticles to the inflamed colonic site is of great interest for inflammatory bowel disease (IBD) treatment. Curcumin (CC) is an anti-inflammatory local agent, which presents poor ADME properties. Hence, we evaluated, both in vitro and in vivo, the local delivery of CC using pH-sensitive polymeric nanoparticles (NPs) combining both poly(lactide-co… CONTINUE READING


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