pH-sensitive micelles based on acid-labile pluronic F68-curcumin conjugates for improved tumor intracellular drug delivery.

@article{Fang2016pHsensitiveMB,
  title={pH-sensitive micelles based on acid-labile pluronic F68-curcumin conjugates for improved tumor intracellular drug delivery.},
  author={Xiao-Bin Fang and Jin-ming Zhang and Xi Xie and Di Liu and Cheng-Wei He and Jian-Bo Wan and Meiwan Chen},
  journal={International journal of pharmaceutics},
  year={2016},
  volume={502 1-2},
  pages={28-37}
}
Curcumin (Cur) is a highly pleiotropic anticancer agent that inhibits cell proliferation and induces apoptosis in cancer cells. A variety of nano-systems constituted by polymer-drug conjugates have been designed to overcome its shortages on water solubility, chemical instability, and poor bioavailability. However, most of them suffer from ineffective… CONTINUE READING