pH-sensitive drug-delivery systems for tumor targeting.


Drug-delivery system responses to stimuli have been well investigated recently. As pH decrease is observed in most solid tumors, drug-delivery systems responsive to the slightly acidic extracellular pH environment of solid tumors have been developed as a general strategy for tumor targeting. Drug vehicles that are sensitive to acidic endosome/lysosome pH have been constructed for efficient drug release in tumor cells. This review explains the mechanisms of acidic pH in the tumor microenvironment and endocytic-related organelles, endosomes and lysosomes. Nanoparticle responses to acidic extracellular pH are discussed, along with approaches for improving tumor-specific therapy. Endosome/lysosome pH-triggered vehicles are reviewed, which achieve rapid drug release in tumor cells and overcome multidrug resistance.

DOI: 10.4155/tde.13.120
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@article{He2013pHsensitiveDS, title={pH-sensitive drug-delivery systems for tumor targeting.}, author={Xi He and Jianfeng Li and Sai An and Chen Jiang}, journal={Therapeutic delivery}, year={2013}, volume={4 12}, pages={1499-510} }