pH-sensitive MRI demarcates graded tissue acidification during acute stroke ― pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI

@article{Guo2016pHsensitiveMD,
  title={pH-sensitive MRI demarcates graded tissue acidification during acute stroke ― pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI},
  author={Yingkun Guo and Iris Yuwen Zhou and Suk-Tak Chan and Yu Wang and Emiri T. Mandeville and Takahiro Igarashi and Eng H. Lo and Xunming Ji and Phillip Zhe Sun},
  journal={NeuroImage},
  year={2016},
  volume={141},
  pages={242-249}
}
pH-sensitive amide proton transfer (APT) MRI provides a surrogate metabolic biomarker that complements the widely-used perfusion and diffusion imaging. However, the endogenous APT MRI is often calculated using the asymmetry analysis (MTRasym), which is susceptible to an inhomogeneous shift due to concomitant semisolid magnetization transfer (MT) and nuclear… CONTINUE READING