pH-responsive DNA-binding activity of Helicobacter pylori NikR.

  title={pH-responsive DNA-binding activity of Helicobacter pylori NikR.},
  author={Yanjie Li and Deborah B Zamble},
  volume={48 11},
Helicobacter pylori NikR (HpNikR) is a nickel-responsive transcription factor. In addition to a role in nickel homeostasis, HpNikR is proposed to serve as a master activator-repressor for H. pylori acid adaptation by directly or indirectly regulating the expression of a battery of genes. One potential mechanism of this regulation is modulation of the DNA-binding activity of HpNikR by the decrease in internal pH that occurs upon exposure to acidic shock. To test this hypothesis, several… CONTINUE READING

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