pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.

@article{Gunathilake2009pHregulatedMA,
  title={pH-regulated mechanisms account for pigment-type differences in epidermal barrier function.},
  author={Roshan Gunathilake and Nanna Y Schurer and Brenda A Shoo and Anna Celli and J P Hachem and Debra C Crumrine and Ganga Sirimanna and Kenneth R. Feingold and Theodora M. Mauro and Peter M Elias},
  journal={The Journal of investigative dermatology},
  year={2009},
  volume={129 7},
  pages={1719-29}
}
To determine whether pigment type determines differences in epidermal function, we studied stratum corneum (SC) pH, permeability barrier homeostasis, and SC integrity in three geographically disparate populations with pigment type I-II versus IV-V skin (Fitzpatrick I-VI scale). Type IV-V subjects showed: (i) lower surface pH (approximately 0.5 U); (ii) enhanced SC integrity (transepidermal water loss change with sequential tape strippings); and (iii) more rapid barrier recovery than type I-II… CONTINUE READING

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