pH modulation of the kinetics of a Ca2(+)-sensitive cross-bridge state transition in mammalian single skeletal muscle fibres.

@article{Metzger1990pHMO,
  title={pH modulation of the kinetics of a Ca2(+)-sensitive cross-bridge state transition in mammalian single skeletal muscle fibres.},
  author={Joseph M Metzger and Richard L Moss},
  journal={The Journal of physiology},
  year={1990},
  volume={428},
  pages={751-64}
}
1. The rate constant of tension redevelopment (ktr) following a rapid release and subsequent re-extension of muscle length has been demonstrated to be Ca2+ sensitive and is thought to reflect the rate-limiting step in the cross-bridge cycle leading to the formation of the strongly bound, force-bearing state. The kinetics of this cross-bridge state transition were investigated at 15 degrees C over a wide range of Ca2+ concentrations while varying pH from 7.00 to 6.20 in rat slow-twitch soleus… CONTINUE READING