pH is a potent modulator of erythroid differentiation.

  title={pH is a potent modulator of erythroid differentiation.},
  author={Todd A. McAdams and William M. Miller and Eleftherios T. Papoutsakis},
  journal={British journal of haematology},
  volume={103 2},
Physiological parameters such as pH and oxygen tension probably play significant roles in the regulation of haemopoiesis in the bone marrow microenvironment, but these roles have yet to be characterized in detail. We have found that changes in culture pH (0.2 units) can cause significant changes in the culture composition of mature cells and colony-forming cells (CFCs), especially in the presence of erythropoietin (Epo). Peripheral blood (PB) CD34+ cells cultured at different pH values (7.15-7… CONTINUE READING

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