pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles.

Abstract

The transport mechanism of urate and p-aminohippurate (PAH) was evaluated in microvillus membrane vesicles isolated from the renal cortex of the mongrel dog. Imposition of a transmembrane pH gradient (pHo less than pH1) markedly accelerated the uptake of [14C]urate and [3H]PAH and caused the transient accumulation ("overshoot") of each anion above its final… (More)

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@article{Blomstedt1980pHGT, title={pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles.}, author={Joseph Blomstedt and Patricia Aronson}, journal={The Journal of clinical investigation}, year={1980}, volume={65 4}, pages={931-4} }