pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery.

@article{Balogh2013pHgradientPI,
  title={pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery.},
  author={Gy{\"o}rgy T Balogh and Judit Mueller and {\'A}rp{\'a}d K{\"o}ncz{\"o}l},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2013},
  volume={49 1},
  pages={
          81-9
        }
}
In the present study we validated a widely used, high-throughput in vitro permeability model (PAMPA) to be used at the early stage of drug discovery for the phospholipidosis (PLD) prediction of drug-like compounds. Regarding the mechanism of action of PLD, our pH-gradient PAMPA system is the first noncell based model to mimic one-way transport of cationic amphiphilic drugs (CADs) from cytosol to the lysosome. Moreover, due to the fact that PLD can mainly occur in lung, liver, brain, kidney and… CONTINUE READING
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