pH-dependent self-assembly of polyalanine peptides.

Abstract

Polyalanine expansions in the nuclear RNA-binding protein PABP2 induce misfolding and aggregation of the protein into insoluble inclusions in muscle tissues and cell nuclei, leading to the disease oculopharyngeal muscular dystrophy (OPMD). We have explored the effect of solvent conditions and alanine repeat number on the propensity of fibril formation in… (More)

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@article{Giri2007pHdependentSO, title={pH-dependent self-assembly of polyalanine peptides.}, author={Kalyan Giri and Nitai P. Bhattacharyya and Soumen Basak}, journal={Biophysical journal}, year={2007}, volume={92 1}, pages={293-302} }