pH-dependent release of platycodin mitigates its gastrointestinal mucosa irritation after oral administration in rats.

Abstract

The present study aimed to evaluate the gastrointestinal mucosa irritation of three platycodin formulations. Platycodin-loaded core pellets were prepared via extrusion-spheronization method and coated with Eudragit(®) L100-55 (L100) or Eudragit(®) S100 (S100) for pH-dependent release. The release of platycodin D from coated pellets exhibited pH dependent… (More)
DOI: 10.1007/s12272-016-0752-6

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Cite this paper

@article{Chen2016pHdependentRO, title={pH-dependent release of platycodin mitigates its gastrointestinal mucosa irritation after oral administration in rats.}, author={Qin Chen and Wen-Wen Yang and Pan Shen and Qing-Ri Cao and Beom-Jin Lee and Jing-hao Cui}, journal={Archives of pharmacal research}, year={2016}, volume={39 6}, pages={811-24} }