pH-dependent pore formation in Semliki forest virus-infected Aedes albopictus cells.

@article{Lanzrein1993pHdependentPF,
  title={pH-dependent pore formation in Semliki forest virus-infected Aedes albopictus cells.},
  author={M. Lanzrein and Robert Weingart and Christoph Kempf},
  journal={Virology},
  year={1993},
  volume={193 1},
  pages={296-302}
}
The plasma membrane properties of Semliki forest virus-infected Aedes cells were studied using whole-cell patch-clamp recording. Cells exhibited a marked increase in membrane conductance, gm (from 0.48 +/- 0.09 nS to 14.2 +/- 10.8 nS) upon exposure to acidic pH (5.6). The membrane potential depolarized from -40.9 +/- 5.2 mV to -2.43 +/- 7.14 mV under these conditions. In uninfected cells, there was no change in gm after lowering the pH. This implies that viral fusion proteins are involved in… CONTINUE READING

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