pH-dependent electrophysiological effects of quinidine and lidocaine on canine cardiac purkinje fibers.

Abstract

We used standard microelectrode techniques to evaluate the effects of lidocaine and quinidine on canine Purkinje fibers at normal pH (7.3) and in the presence of acidosis (pH 6.9). Acidosis alone reduced resting potential, action potential amplitude, and Vmax, while increasing APD90 and conduction time. Lidocaine concentrations of 6 x 10(-6) to 1.5 x 10(-5… (More)

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@article{Nattel1981pHdependentEE, title={pH-dependent electrophysiological effects of quinidine and lidocaine on canine cardiac purkinje fibers.}, author={Stanley Nattel and Victor Elharrar and D. P. Zipes and Jessica N Cooke Bailey}, journal={Circulation research}, year={1981}, volume={48 1}, pages={55-61} }