pH and near-infrared light dual-stimuli responsive drug delivery using DNA-conjugated gold nanorods for effective treatment of multidrug resistant cancer cells.

@article{Zhang2016pHAN,
  title={pH and near-infrared light dual-stimuli responsive drug delivery using DNA-conjugated gold nanorods for effective treatment of multidrug resistant cancer cells.},
  author={Wenjun Zhang and Feihu Wang and Y. K. Wang and Jining Wang and Yanna Yu and Shengrong Guo and Rongjun Chen and Dejian Zhou},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2016},
  volume={232},
  pages={9-19}
}
A thiolated pH-responsive DNA conjugated gold nanorod (GNR) was developed as a multifunctional nanocarrier for targeted, pH-and near infrared (NIR) radiation dual-stimuli triggered drug delivery. It was further passivated by a thiolated poly(ethylene glycol)-biotin to improve its cancer targeting ability by specific binding to cancer cell over-expressed… CONTINUE READING