pH and calcium regulate the water permeability of aquaporin 0.

  title={pH and calcium regulate the water permeability of aquaporin 0.},
  author={Karin L. N{\'e}meth-Cahalan and James Edwin Hall},
  journal={The Journal of biological chemistry},
  volume={275 10},
Aquaporins increase the water permeability in many cell types across many species. We investigated the effects of external pH and Ca(2+) on water permeability of Xenopus oocytes injected with aquaporin cRNA by measuring the rate of swelling in hypotonic solutions. Lowering pH to 6.5 increased the water permeability of aquaporin (AQP0) 3.4 +/- 0.4-fold. Diethylpyrocarbonate pretreatment increased water permeability 4.2 +/- 0.5-fold and abolished pH sensitivity, suggesting that the pH regulation… CONTINUE READING
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