pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistance in Cancer Treatment.

@article{Li2016pHAN,
  title={pH- and NIR Light-Responsive Polymeric Prodrug Micelles for Hyperthermia-Assisted Site-Specific Chemotherapy to Reverse Drug Resistance in Cancer Treatment.},
  author={Zuhong Li and Hai-Bo Wang and Yangjun Chen and Youxiang Wang and Huan Li and Haijie Han and Ting-Ting Chen and Qiao Jin and Jian Ji},
  journal={Small},
  year={2016},
  volume={12 20},
  pages={2731-40}
}
Despite the exciting advances in cancer chemotherapy over past decades, drug resistance in cancer treatment remains one of the primary reasons for therapeutic failure. IR-780 loaded pH-responsive polymeric prodrug micelles with near infrared (NIR) photothermal effect are developed to circumvent the drug resistance in cancer treatment. The polymeric prodrug micelles are stable in physiological environment, while exhibit fast doxorubicin (DOX) release in acidic condition and significant… CONTINUE READING

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