pH-Responsive Poly(ethylene glycol)/Poly(L-lactide) Supramolecular Micelles Based on Host-Guest Interaction.

@article{Zhang2015pHResponsivePG,
  title={pH-Responsive Poly(ethylene glycol)/Poly(L-lactide) Supramolecular Micelles Based on Host-Guest Interaction.},
  author={Zhe Zhang and Qiang Lv and Xiaoye Gao and Li Chen and Yue Cao and Shuangjiang Yu and Chaoliang He and Xuesi Chen},
  journal={ACS applied materials & interfaces},
  year={2015},
  volume={7 16},
  pages={8404-11}
}
pH-responsive supramolecular amphiphilic micelles based on benzimidazole-terminated poly(ethylene glycol) (PEG-BM) and β-cyclodextrin-modified poly(L-lactide) (CD-PLLA) were developed by exploiting the host-guest interaction between benzimidazole (BM) and β-cyclodextrin (β-CD). The dissociation of the supramolecular micelles was triggered in acidic environments. An antineoplastic drug, doxorubicin (DOX), was loaded into the supramolecular micelles as a model drug. The release of DOX from the… CONTINUE READING