pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase.

@article{Yenush2005pHResponsivePR,
  title={pH-Responsive, posttranslational regulation of the Trk1 potassium transporter by the type 1-related Ppz1 phosphatase.},
  author={Lynne Yenush and Stephanie Merchan and James Holmes and Ram{\'o}n Serrano},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 19},
  pages={8683-92}
}
Intracellular pH and K+ concentrations must be tightly controlled because they affect many cellular activities, including cell growth and death. The mechanisms of homeostasis of H+ and K+ are only partially understood. In the yeast Saccharomyces cerevisiae, proton efflux is mediated by the Pma1 H+-ATPase. As this pump is electrogenic, the activity of the Trk1 and -2 K+ uptake system is crucial for sustained Pma1p operation. The coordinated activities of these two systems determine cell volume… CONTINUE READING