pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties

@article{Hsieh2012pHInducedPB,
  title={pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties},
  author={Yi-Ling Hsieh and Grace A. Ilevbare and B. Van Eerdenbrugh and K. Box and Manuel Sanchez-Felix and L. Taylor},
  journal={Pharmaceutical Research},
  year={2012},
  volume={29},
  pages={2738-2753}
}
  • Yi-Ling Hsieh, Grace A. Ilevbare, +3 authors L. Taylor
  • Published 2012
  • Chemistry, Medicine
  • Pharmaceutical Research
  • ABSTRACTPurposeTo examine the precipitation and supersaturation behavior of ten weak bases in terms of the relationship between pH-concentration-time profiles and the solid state properties of the precipitated material.MethodsInitially the compound was dissolved at low pH, followed by titration with base to induce precipitation. Upon precipitation, small aliquots of acid or base were added to induce slight subsaturation and supersaturation respectively and the resultant pH gradient was… CONTINUE READING
    88 Citations

    Figures, Tables, and Topics from this paper.

    Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs.
    • Ashish L. Sarode, P. Wang, S. Obara, D. Worthen
    • Chemistry, Medicine
    • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
    • 2014
    • 62
    Impact of polymers on the precipitation behavior of highly supersaturated aqueous danazol solutions.
    • 41

    References

    SHOWING 1-10 OF 49 REFERENCES
    Chasing equilibrium: measuring the intrinsic solubility of weak acids and bases.
    • 90
    Equilibrium versus kinetic measurements of aqueous solubility, and the ability of compounds to supersaturate in solution--a validation study.
    • 76
    pH-metric solubility. 3. Dissolution titration template method for solubility determination.
    • A. Avdeef, C. Berger
    • Chemistry, Medicine
    • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
    • 2001
    • 88
    pH-metric log P. II: Refinement of partition coefficients and ionization constants of multiprotic substances.
    • A. Avdeef
    • Chemistry, Medicine
    • Journal of pharmaceutical sciences
    • 1993
    • 186