pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits.

@article{Hesselager2004pHDA,
  title={pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits.},
  author={Mette Hesselager and Daniel Brunicardi Timmermann and Philip Ki{\ae}r Ahring},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 12},
  pages={11006-15}
}
The exact subunit combinations of functional native acid-sensing ion channels (ASICs) have not been established yet, but both homomeric and heteromeric channels are likely to exist. To determine the ability of different subunits to assemble into heteromeric channels, a number of ASIC1a-, ASIC1b-, ASIC2a-, ASIC2b-, and ASIC3-containing homo- and heteromeric channels were studied by whole-cell patch clamp recordings with respect to pH sensitivity, desensitization kinetics, and level of sustained… CONTINUE READING
Highly Influential
This paper has highly influenced 23 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 113 extracted citations

Similar Papers

Loading similar papers…