pH-Cleavable Nucleoside Lipids: A New Paradigm for Controlling the Stability of Lipid-Based Delivery Systems.

@article{Oumzil2015pHCleavableNL,
  title={pH-Cleavable Nucleoside Lipids: A New Paradigm for Controlling the Stability of Lipid-Based Delivery Systems.},
  author={Khalid Oumzil and S{\'e}bastien Benizri and Giovanni Tonelli and Cathy Staedel and Ananda Appavoo and Max Chaffanet and Laurence Navailles and Philippe Barth{\'e}l{\'e}my},
  journal={ChemMedChem},
  year={2015},
  volume={10 11},
  pages={1797-801}
}
Lipid-based delivery systems are an established technology with considerable clinical acceptance and several applications in human. Herein, we report the design, synthesis and evaluation of novel orthoester nucleoside lipids (ONLs) for the modulation of liposome stability. The ONLs contain head groups with 3'-orthoester nucleoside derivatives featuring positive or negative charges. The insertion of the orthoester function in the NL structures allows the formation of pH-sensitive liposomes. ONL… CONTINUE READING
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