pH Alters PEG-mediated fusion of phosphatidylethanolamine-containing vesicles.

  title={pH Alters PEG-mediated fusion of phosphatidylethanolamine-containing vesicles.},
  author={Hirak Chakraborty and Tanusree Sengupta and Barry R. Lentz},
  journal={Biophysical journal},
  volume={107 6},
Here, we examine the different mechanisms of poly(ethylene glycol)-mediated fusion of small unilamellar vesicles composed of dioleoylphosphatidylcholine/dioleoylphosphatidylethanolamine (DOPE)/sphingomyelin/cholesterol in a molar ratio of 35:30:15:20 at pH 7.4 versus pH 5. In doing so, we test the hypothesis that fusion of this lipid mixture should be influenced by differences in hydration of DOPE at these two pH values. An examination of the literature reveals that DOPE should be less hydrated… CONTINUE READING
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