pH/redox dual‐sensitive dextran nanogels for enhanced intracellular drug delivery

@article{Curcio2017pHredoxDD,
  title={pH/redox dual‐sensitive dextran nanogels for enhanced intracellular drug delivery},
  author={Manuela Curcio and Luis Diaz-Gomez and Giuseppe Cirillo and Angel Concheiro and Francesca Iemma and Carmen Alvarez‐Lorenzo},
  journal={European Journal of Pharmaceutics and Biopharmaceutics},
  year={2017},
  volume={117},
  pages={324–332}
}
Graphical abstract Figure. No caption available. HighlightspH/redox dual‐sensitive dextran nanogels.Drug release carriers in cancer chemotherapeutics.pH dependent internalization in cancer cells. ABSTRACT pH/redox dual‐responsive nanogels (DEX‐SS) were prepared by precipitation polymerization of methacrylated dextran (DEXMA), 2‐aminoethylmethacrylate (AEMA) and N,N′‐bis(acryloyl)cystamine (BAC), and then loaded with methotrexate (MTX). Nanogels were spherical and exhibited homogeneous size… Expand
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